Stefan Steyn, PhD
Research Fellow
Bio:
Dr. Stefanus J. Steyn is a Research Fellow in the Pharmacokinetics, Dynamics, and Metabolism (PDM) Department at Pfizer in Cambridge, Massachusetts, where he serves as the Inflammation and Immunology Therapeutic Area DMPK Portfolio Lead. In this role, he is responsible for shaping PDM research strategy and guiding ADME strategies across small- and large-molecule discovery programs. Dr. Steyn earned his Ph.D. in Pharmaceutical Chemistry from North-West University in South Africa and completed postdoctoral training with Professor Neal Castagnoli at Virginia Tech in Blacksburg, Virginia, before joining Pfizer in 2001. His current work focuses on defining ADME strategies for beyond-rule-of-five (bRo5) modalities, with particular interest in PROTACs and the relationship between physicochemical properties and oral absorption. His research aims to inform improved design strategies for complex therapeutic modalities.