Going the Distance: Unlocking Peptides and Biologics with In Situ Gels and Ready-to-Inject Microparticles

Session details:

• In Situ Hydrogel Depots with low Burst: Low-viscosity polymer backbones engineered to transition into uniform, biodegradable depots in vivo, preserving tertiary structure and preventing premature burst release for fragile peptides and biologics.
• Ready-to-Inject Microparticle Platform: Pre-crosslinked, ready-to-inject microparticles that decouple particle manufacturing from drug loading—protecting sensitive peptides and small molecules from organic solvents, thermal stress, and standard scale-up hazards.
• Accelerated Development via Persist AI & Automation: Leveraging Persist AI’s closed-loop robotics and machine learning workflows to rapidly screen excipient compatibility, optimize target release kinetics, and compress preclinical formulation timelines from years into months.
• A Tunable Delivery Portfolio Built for Translation: A deep dive into Pendant Biosciences' multi-platform capabilities, highlighting modular release kinetics, seamless ready-to-inject SC administration, and reproducible process chemistry designed to de-risk clinical development.