Rational Design of High-Concentration Subcutaneous Biologics: Integrating Modeling, Novel Excipients, and Spray-Dried Suspension Technologies

Session details:

Development of high-concentration subcutaneous biologics formulations for patient-centric therapies is often constrained by challenges related to viscosity and stability. This presentation highlights an integrated formulation development strategy that expands the formulation toolbox by combining molecular dynamics-based computational modeling, innovative synthetic sugar excipients, and spray-dried suspension technologies to address these limitations.

Key Points

• Using molecular dynamics-based computational modeling for novel excipient selection & formulation screening for high-concentration biologics.
• Learning how novel synthetic sugar excipients can reduce viscosity while maintaining of high-concentration subcutaneous formulations.
• Explore how non-aqueous suspensions of spray-dried biologic formulations can push the envelope in concentration for subcutaneous delivery.